Waking from a coma, Vanessa finds lone soldier Axel protecting her from a vampire apocalypse called "The Rising" and discovers she has unusual powers.
Three years before her awakening, Vanessa is a single mom in Seattle when a volcanic eruption and a rash of killings signal the start of "The Rising."
When their UV light source is damaged, Vanessa and Axel must scavenge outside for parts. Flesh reveals the truth about Vanessa to his former comrades.
Searching for their lost loved ones, Vanessa and Mohamad sneak out of the hospital, while Doc and Axel discover that a suicide is not what it appears.
Captured by vampire leader Julius, a surprised Vanessa finds a familiar face in his flock. New arrivals at the hospital wrest control away from Axel.
While Vanessa and Susan attempt to escape from Julius through underground tunnels, the schism widens between two groups of survivors at the hospital.
Opposing forces under Julius and Dmitri clash during a siege of the hospital while the remaining survivors consider permanently leaving the facility.
Mohamad tries to stay alive and catch up to the survivors who are following Axel to his former military base, only to find the site abandoned.
Trapped in an underground lab called "The Farm," the group encounters a feral vampire and deadly radiation while Mohamad makes a friend on the road.
After suffering a grievous loss, Vanessa and the survivors find comfort at Eden, a seemingly peaceful human community that conceals a dark bargain.
Taking refuge at Susan's childhood home, the survivors face a shocking revelation about a member of the group while Julius begins tracking Vanessa.
Traveling to a vampire-controlled camp, Vanessa and Mohamad are trailed by an increasingly dangerous Sam, while Julius and Dmitri meet face to face.
Revelations, betrayals and reversals are in store for everyone when Vanessa becomes a captive of Dmitri, whose rule is not as ironclad as he believes.
Vanessa and Scarlett suffer a loss but gain an oath of fealty from the First Elder. Julius and the others are held hostage by Harrison and his troops.
Seeking its lost totem, the First Elder leads Vanessa, Scarlett and Axel to a decaying former insane asylum that's linked to a Van Helsing ancestor.
Vanessa is transported into the life of her ancestor Lily Van Helsing in colonial Hong Kong, where she fights the B'ah, another vampire Elder.
After they become daywalkers, Ivory and Scab return to the Sisterhood to find it in ruins. Sam's visions lead him to begin training a worthy protégé.
Doc, Jolene, Julius and Flesh settle into new lives in Denver. Vanessa, Scarlett and Axel arrive in San Francisco searching for the Second Elder.
The Denver contingent learns the rules of life in the safe zone -- along with some disturbing secrets. Vanessa prepares for a showdown.
Trapped underground, Mohamad has a vision that leads him to freedom. Axel takes a band of survivors to Denver. The Sisterhood become daywalkers.
Vanessa and Scarlett follow a map to an island where the Third Elder is entombed, but their quarry's identity unexpectedly causes them to hesitate.
To force Doc to continue her research, Denver officials arrest Jolene. Axel gets his crew safely to the city just as Ivory and the Sisterhood attack.
Ensnared in a gruesome trap, Vanessa is visited by the ghosts of her past, who force her to reckon with the dark impulses growing inside her.
Axel returns to his hometown, where he finds a familiar face among the survivors fighting a band of daywalkers. Sam embarks on a search for Mohamad.
Axel is reunited with Scarlett, but after he's blinded while fighting daywalkers, they seek help from a mysterious man living alone in the wilderness.
The paths of Vanessa, Scarlett, Axel, Mohamad and Sam converge in a gruesome confrontation between light and darkness that claims several casualties.
Vanessa's long-awaited reunion with Dylan isn't what she dreamed it would be. A barely alive Dmitri flees, while others meet a final reckoning.
Mohamad rescues Vanessa and Dylan, who then have a fateful clash with Julius. Two long-lost survivors reunite, but neither are who they once were.
Vanessa's attempts to keep Dylan alive force her to make a series of wrenching choices. A mysterious vampire assails a group of juvenile delinquents.
Vanessa and Julius are rescued from a skinners' camp by a band of survivors living in the forest. Sam takes Felix, one of the delinquents, captive.
After a vengeful Sam massacres a camp full of children, Vanessa goes on the warpath trying to find him, leading to a brutal and bloody confrontation.
As Dmitri takes extraordinary steps to rebuild his forces, visions lead Vanessa back to a secret base where lost memories of her childhood resurface.
Dmitri's connection to Vanessa's mysterious past is revealed, while Scab recruits troops for his new master. Axel's return to normal is death-defying.
Searching for Vanessa, her group encounters a fortress of suspiciously friendly police officers. Flesh and Lucky seek Mohamad but find Dmitri's army.
Dmitri closes in on Doc and Julius while Axel and Scarlett hide from the Sisters. Scarlett's past as a vampire hunter-in-training is revealed.
In a remote mountain laboratory, Vanessa awakens to find a secret program underway to create a cure for vampirism -- and she's the next test subject.
Sam's traumatic childhood is revealed in flashbacks while he forces a human prisoner to treat Mohamad, who is near death from his grievous wounds.
The splintered group converges at the sanctuary of Crooked Falls, but new behaviors displayed by a pack of ferals alert them to a growing danger.
Scarlett and an ally from Crooked Falls penetrate the mountain tomb of the Elder, but Dmitri is two steps ahead of them in freeing the ancient evil.